Serenade Of The Seas Panama Canal Cruise From San Diego - September 19, 2025
13 Night Panama Canal Eastward Cruise
Panama Canal one way cruise departs from San Diego on Friday September 19, 2025. The 13 day cruise ends with the arrival of Serenade Of The Seas in Miami on Thursday October 2, 2025.
- Read reviews of Serenade Of The Seas
- Check prices on Serenade Of The Seas cruises
- Serenade Of The Seas deck plans, cabin types, dining options and amenities
- Follow TheCruiseNexus on Facebook for more cruise ideas and information
Ports of Call

Puerto Vallarta, Mexico
The cruise terminal at Puerto Vallarta is about 25 miles inland from the Pacific Ocean, on the Bahia de Banderas. It's about 1200 miles southeast of Los Angeles.

Puntarenas, Costa Rica
Puntarenas is a port town on the Gulf of Nicoya on the west side of Costa Rica, about 50 miles west of San Jose.
Departure Port: San Diego Cruise Ship Terminal
Directions: Google Maps - Apple Maps
For the night before your cruise: Hotels near San Diego Cruise Ship Terminal
Wyndham San Diego Bayside
1355 N Harbor Drive
0.2 miles from cruise port
Compare prices for September 18th
InterContinental San Diego, an IHG Hotel
901 Bayfront Court
0.2 miles from cruise port
Compare prices for September 18th
Hampton Inn San Diego Downtown
1531 Pacific Hwy
0.4 miles from cruise port
Compare prices for September 18th
The Guild Hotel, San Diego, a Tribute Portfolio Hotel
500 W Broadway
0.4 miles from cruise port
Compare prices for September 18th
Pacific Inn and Suites
1655 Pacific Hwy
0.4 miles from cruise port
Compare prices for September 18th
Best Western Plus Bayside Inn
555 W Ash Street
0.4 miles from cruise port
Compare prices for September 18th
Residence Inn by Marriott San Diego Downtown
1747 Pacific Hwy
0.5 miles from cruise port
Compare prices for September 18th
Hotel Republic San Diego, Autograph Collection
421 W B St
0.5 miles from cruise port
Compare prices for September 18th
Top 10 future cruises from San Diego
15 Night Panama Canal
Zuiderdam: Departs on February 27, 2026
15 Night Panama Canal: Mexico and Costa Rica
Norwegian Star: Departs on April 3, 2027
16 Night Panama Canal Cruise
Radiance Of The Seas: Departs on October 4, 2025
17 Night Panama Canal
Koningsdam: Departs on November 1, 2025
17 Night Panama Canal
Eurodam: Departs on October 9, 2025
15 Night Panama Canal: Mexico and Costa Rica
Norwegian Jade: Departs on February 12, 2026
20 Night Panoramic Panama Canal San Diego to New York
Oceania Insignia: Departs on July 3, 2025
11 Night Mexican Riviera and Pacific Coast
Zaandam: Departs on April 25, 2026
25 Night Pacific Coastal and Circle Hawaii Collector
Nieuw Amsterdam: Departs on April 4, 2026
18 Night Baja Peninsula, Mexican Riviera and Pacific Coast
Zaandam: Departs on April 18, 2026
More cruises scheduled for Friday September 19, 2025
12 Night Northern Sites, Coastal Delights Amsterdam To Barcelona
Seven Seas Mariner from Amsterdam
11 Night Gilded New England New York To Montreal
Seven Seas Splendor from New York City
16 Night Panama Canal Eastbound
Celebrity Summit from Los Angeles
22 Night Pacific Passage and Jewels Of Japan
Seabourn Quest from Vancouver
10 Night Classic Canada and New England
Majestic Princess from Boston
14 Night Mediterranean From Toulon-La Seyne-sur-Mer
Costa Fortuna from Piraeus (Athens)
12 Night Mediterranean From Savona
Costa Fortuna from Piraeus (Athens)
9 Night Greece and Italy Explorer Italy
SeaDream II from Civitavecchia (Rome)
11 Night Europe: Germany, Norway and Poland
Norwegian Dawn from Oslo
10 Night Greek Isles and Adriatic
Celebrity Eclipse from Ravenna
Cruise Updates
London to Barcelona in OctoberSeven day cruise aboard Viking Saturn is a trip through the Strait of Gibraltar with visits to several coastal spots in Spain
Valentine's Day 2026 Cruises From Fort Lauderdale
Get ready for Valentine's Day 2026 with one of these amazing cruises departing from Fort Lauderdale
Oceania Schedule Update
619 opportunities to explore the world aboard one of Oceania Cruise Line's eight ships
Cruises Aboard Rotterdam
Holland America's cruise ship Rotterdam spends the summers making fantastical cruises to the Arctic Circle and the fjords of Norway
October 2025 Top Cruises
Our updated list of the most interesting cruises in the world scheduled for departure in October
