Island Princess Panama Canal Cruise From Los Angeles - October 22, 2025
16 Night Panama Canal - Ocean to Ocean
Panama Canal one way cruise departs from Los Angeles on Wednesday October 22, 2025. The 16 day cruise ends with the arrival of Island Princess in Fort Lauderdale on Friday November 7, 2025. The Halloween holiday (October 31, 2025) is during the cruise.
- Read reviews of Island Princess
- Check prices on Island Princess cruises
- Island Princess deck plans, cabin types, dining options and amenities
- Follow TheCruiseNexus on Facebook for more cruise ideas and information
Ports of Call

Puerto Vallarta, Mexico
The cruise terminal at Puerto Vallarta is about 25 miles inland from the Pacific Ocean, on the Bahia de Banderas. It's about 1200 miles southeast of Los Angeles.

Puntarenas, Costa Rica
Puntarenas is a port town on the Gulf of Nicoya on the west side of Costa Rica, about 50 miles west of San Jose.

Panama City, Panama
Panama City is the capital city of Panama with a population of over 450,000. It's on the Pacific coast at the eastern end of the Panama Canal.

Willemstad, Curacao
Willemstad is the capital of Curacao, at the southern edge of the Caribbean, less than 50 miles from the northern coast of Venezuela.
Departure Port: World Cruise Center
Directions: Google Maps - Apple Maps
For the night before your cruise: Hotels near World Cruise Center
Sunrise Hotel San Pedro
525 S Harbor Blvd
0.5 miles from cruise port
Compare prices for October 21st
Crowne Plaza Los Angeles Harbor Hotel
601 S Palos Verdes St
0.6 miles from cruise port
Compare prices for October 21st
All Star Inn
411 South Pacific Avenue
0.7 miles from cruise port
Compare prices for October 21st
Best Western Plus San Pedro Hotel & Suites
111 South Gaffey Street
0.9 miles from cruise port
Compare prices for October 21st
Vagabond Inn San Pedro
215 S Gaffey St
0.9 miles from cruise port
Compare prices for October 21st
Americas Best Value Inn Rancho Palos Verdes
29601 South Western Avenue
1.8 miles from cruise port
Compare prices for October 21st
DoubleTree by Hilton San Pedro - Port of Los Angeles
2800 Via Cabrillo Marina
1.9 miles from cruise port
Compare prices for October 21st
Monterey Inn Hotel
233 N. Avalon Blvd
2.0 miles from cruise port
Compare prices for October 21st
Top 10 future cruises from Los Angeles
18 Night World Cruise: Hawaii and French Polynesia
Seabourn Sojourn: Departs on January 6, 2026
19 Night Panama Canal Passage
Seabourn Quest: Departs on April 7, 2026
16 Night Panama Canal - Ocean to Ocean
Island Princess: Departs on February 9, 2026
16 Night Panama Canal: Mexico and Jamaica
Norwegian Bliss: Departs on October 13, 2026
19 Night Panama Canal: Mexico and Jamaica
Norwegian Bliss: Departs on October 13, 2026
16 Night Panama Canal - Ocean to Ocean
Coral Princess: Departs on October 28, 2025
16 Night Panama Canal - Ocean to Ocean
Caribbean Princess: Departs on September 30, 2025
16 Night Panama Canal - Ocean to Ocean
Grand Princess: Departs on September 15, 2025
27 Night Panama Canal and Caribbean Adventurer
Grand Princess: Departs on September 15, 2025
16 Night Stars and Salsa Los Angeles To Miami
Seven Seas Grandeur: Departs on January 25, 2026
More cruises scheduled for Wednesday October 22, 2025
14 Night Transatlantic Cruise
Odyssey Of The Seas from Civitavecchia (Rome)
26 Night Traversing Mediterranean Crossing: Corsica and Morocco
Oosterdam from Piraeus (Athens)
11 Night Colorful Canopies Montreal To New York
Seven Seas Splendor from Montreal
12 Night Sunset Over Tuscany Trieste To Barcelona
Seven Seas Mariner from Trieste
14 Night Western Europe Passage
Star Princess from Barcelona
11 Night Traversing The Mediterranean: Naples and Corsica
Oosterdam from Piraeus (Athens)
16 Night Star Collector: Italy and Greece Odyssey
Star Legend from Piraeus (Athens)
16 Night Grand Voyage: Nice To Las Palmas
Star Flyer from Villefranche (Nice)
9 Night Europe: France, Spain, Portugal and Belgium
Norwegian Star from Southampton
13 Night Australia
Celebrity Solstice from Sydney
Cruise Updates
Miami to Rome Next MarchJoin the crew of Oceania Nautica for a 35-day transatlantic voyage plus tour of the Mediterranean Sea
Top 10 Cruises from Miami in November
Celebrate the early days of the holiday season with one of these memorable cruises scheduled to depart from Miami in November
Cruises to Vigo Spain
Port city on the Atlantic coast of Spain is a popular stop for cruises traveling between western Europe and the Mediterranean
London to Barcelona in October
Seven day cruise aboard Viking Saturn is a trip through the Strait of Gibraltar with visits to several coastal spots in Spain
Valentine's Day 2026 Cruises From Fort Lauderdale
Get ready for Valentine's Day 2026 with one of these amazing cruises departing from Fort Lauderdale
