Norwegian Encore Panama Canal Cruise From San Francisco - October 21, 2025

18 Night Panama Canal: Mexico and Colombia


Panama Canal one way cruise departs from San Francisco on Tuesday October 21, 2025. The 18 day cruise ends with the arrival of Norwegian Encore in Miami on Saturday November 8, 2025. The Halloween holiday (October 31, 2025) is during the cruise.



Ports of Call

October 23, 2025
Glacier Bay, Alaska photo

Glacier Bay, Alaska

Glacier Bay National Park and Preserve is 3.3 million acres of mountains, forests, glaciers and fjords. Most cruises to Alaska visit here for views of the glaciers.

October 25, 2025
Cabo San Lucas, Mexico photo

Cabo San Lucas, Mexico

Cabo San Lucas is at the southern tip of the Baja California peninsula. It's a popular resort destination as well as cruise ship port of call.

October 26, 2025
Puerto Vallarta, Mexico photo

Puerto Vallarta, Mexico

The cruise terminal at Puerto Vallarta is about 25 miles inland from the Pacific Ocean, on the Bahia de Banderas. It's about 1200 miles southeast of Los Angeles.

October 28, 2025
Acapulco, Mexico photo

Acapulco, Mexico

Acapulco is a classic cruise destination on the Pacific Coast of Mexico, about 1600 miles southeast of Los Angeles

October 30, 2025
Puerto Quetzal, Guatemala photo

Puerto Quetzal, Guatemala

Puerto Quetzal is a port town on the Pacific Ocean coast of Guatemala. Guatemala City, the nation's capital, is about 60 miles inland from here.

November 3, 2025
Panama City, Panama photo

Panama City, Panama

Panama City is the capital city of Panama with a population of over 450,000. It's on the Pacific coast at the eastern end of the Panama Canal.


Departure Port: San Francisco Cruise Terminal

Directions: Google Maps - Apple Maps

For the night before your cruise: Hotels near San Francisco Cruise Terminal

Europa Hotel


310 Columbus Avenue
0.6 miles from cruise port
Compare prices for October 20th

San Remo Hotel


2237 Mason Street
0.6 miles from cruise port
Compare prices for October 20th

Hotel North Beach


935 Kearny Street
0.6 miles from cruise port
Compare prices for October 20th

Hotel Zephyr


250 Beach Street
0.6 miles from cruise port
Compare prices for October 20th

Hotel Zoe Fisherman's Wharf


425 North Point
0.7 miles from cruise port
Compare prices for October 20th

Hotel Riu Plaza Fisherman's Wharf


2500 Mason St
0.7 miles from cruise port
Compare prices for October 20th

Wharf Inn


2601 Mason St
0.7 miles from cruise port
Compare prices for October 20th

Club Quarters Hotel in San Francisco


424 Clay St
0.7 miles from cruise port
Compare prices for October 20th


Top 10 future cruises from San Francisco

16 Night Panama Canal - Ocean to Ocean

Island Princess: Departs on December 7, 2025

16 Night Panama Canal

Carnival Legend: Departs on October 6, 2025

18 Night Panama Canal: Mexico, Costa Rica and Colombia

Norwegian Joy: Departs on October 2, 2025

20 Night Ultimate Alaska Solstice (with Glacier Bay National Park)

Ruby Princess: Departs on June 12, 2026

11 Night Mexican Riviera

Ruby Princess: Departs on March 7, 2026

16 Night Hawaiian Islands

Ruby Princess: Departs on January 29, 2026

16 Night Hawaiian Islands

Ruby Princess: Departs on January 2, 2026

16 Night Hawaiian Islands Holiday

Ruby Princess: Departs on December 17, 2025

16 Night Hawaiian Islands

Ruby Princess: Departs on December 1, 2025

15 Night Hawaii

Carnival Legend: Departs on September 21, 2025



More cruises scheduled for Tuesday October 21, 2025

23 Night Panama Canal and Pacific Coast

Coral Princess from Vancouver

26 Night Southeast Asia

Viking Orion from Hong Kong

9 Night Empires Of The Mediterranean

Viking Saturn from Venice

14 Night Southeast Asia and Hong Kong

Viking Orion from Hong Kong

24 Night Southampton To Lisbon

Silver Dawn from Southampton

15 Night Brisbane To Darwin

Silver Nova from Brisbane

12 Night Southampton To Lisbon

Silver Dawn from Southampton

16 Night MSC Grand Voyages

MSC Divina from Valencia

26 Night Mediterranean Grand Adventure

Sun Princess from Civitavecchia (Rome)

11 Night Grand Mediterranean

Sun Princess from Civitavecchia (Rome)



Cruise Updates

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Start planning your transatlantic or fjord-viewing cruise departing next June


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Plan now for an early season trip to Alaska with these Memorial Day cruises from Seattle


Cruises to Portland

Coastal city in Maine is a popular stop on New England cruises and the occasional transatlantic voyage


Hawaii and Alaska in October

Tour Hawaii and catch the end of the Alaska cruise season with this 16-day cruise aboard Norwegian Sun that departs from Honolulu on October 1st


Port Canaveral New Year Cruises

Start 2026 afloat with one of the great cruises from Port Canaveral that will be at sea on New Year's Day


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